aroM — Aspergillus fumigatus

Summary

AFU1G13740 (symbol aroM) in Aspergillus fumigatus on chromosome 1 encodes a pentafunctional AroM protein that catalyses five sequential steps of the shikimate pathway. The product possesses 3-dehydroquinate synthase, 3-dehydroquinate dehydratase, shikimate kinase, shikimate 3-dehydrogenase (NADP+), and 3-phosphoshikimate 1-carboxyvinyltransferase activities (EC 4.2.3.4, 1.1.1.25, 2.5.1.19, 2.7.1.71, 4.2.1.10). It is annotated to shikimate kinase activity, ATP binding, and metal binding, and localises to the cytoplasm. The gene is associated with aromatic amino acid family biosynthesis and the shikimate pathway. Related genes in other species link these pentafunctional enzymes to the core shikimate pathway.