SFP1 — Aspergillus fumigatus

Summary

AFU1G14750 (AfSFP1) on chromosome 1 of Aspergillus fumigatus encodes a C2H2-type zinc-finger transcription factor with DNA-binding transcription activator activity specific for RNA polymerase II. The protein localises to both the nucleus and cytosol and is associated with positive regulation of ribosome biogenesis, ribosomal protein gene transcription, RNA anabolism, sporulation, and hyphal growth. Phenotypic associations link AfSFP1 to altered colony colour, vacuolar transport, mating-type switching, pheromone sensitivity, polyploidy, pexophagy, hydrostatic pressure resistance, filamentous growth, cell cycle progression through G2/M and G1 phases, entry into stationary phase, necrotic cell death, autophagy, alkaline pH resistance, and critical cell size at the G1 checkpoint. The gene is also linked to stress responses and mitophagy through studies of related genes in other species.