AUS1 — Aspergillus fumigatus

Summary

AFU1G17440 (AUS1, abcA) on Aspergillus fumigatus chromosome 1 encodes an ABC transporter of the PDR/CDR subfamily, possessing ATP-binding and ATP hydrolase activities. The gene is associated with steroidogenesis, ergosterol anabolism, carbohydrate metabolism, and xenobiotic detoxification via plasma membrane export. It is linked to the plasma membrane and to responses to toxic substances, homologous recombination, mating, cell growth, and hypersensitivity. Phenotypic associations include abnormal small molecule transport, increased sporulation rate, altered vacuolar distribution and transport, delayed exit from G0, decreased cell death rate, and abnormal replicative and chronological lifespan. The gene is also connected to altered nutrient uptake, cell cycle progression, pseudohyphal growth, and shmoo formation. Studies of related genes in other species link the family to plant height, leaf number, root length, drought tolerance, and oxidative stress response, as well as to reduced virulence.