Arp1 — Aspergillus fumigatus

Summary

AFU2G00410 (Arp1) on chromosome 2 of Aspergillus fumigatus encodes an amidase family protein with urea carboxylase, allophanate hydrolase, glutaminyl-tRNA synthase (glutamine-hydrolyzing), and lyase activities, and binds ATP and metal ions. The gene is associated with DHN-melanin biosynthesis, L-phenylalanine breakdown, urea breakdown, glutaminyl-tRNAGln biosynthesis via transamidation, pigmentation, pigment anabolism, immune evasion, melanin anabolism, sporulation, and mitochondrial translation. Its product localizes to the glutamyl-tRNA(Gln) amidotransferase complex and mitochondria. Studies of related genes in other species link the family to allophanate hydrolase (EC 3.5.1.54) and glutaminyl-tRNA synthase activities (EC 6.3.4.6, 6.3.5.7).