SLN1 — Aspergillus fumigatus

Summary

AFU2G00660, also known as SLN1, tcsB, or AfSLN1 in Aspergillus fumigatus, encodes a hybrid histidine kinase with osmosensor, peroxide sensor, and histidine phosphotransfer kinase activities, and is also annotated with DNA binding transcription factor activity. This protein is associated with the phosphorelay signal transduction system, the high-osmolarity glycerol (HOG) response, cellular responses to reactive oxygen species and farnesol, and the regulation of conidiophore development, conidium formation, biofilm formation, cell wall assembly, filamentous growth, and host invasion. It localizes to the plasma membrane, cytoplasm, and nucleus. The gene is linked to pulmonary aspergillosis and has been studied in a Galleria mellonella infection model. Related genes in other species connect the family to osmolarity sensing via a two-component system.