sdeA — Aspergillus fumigatus

Summary

AFU2G02130 (symbol sdeA) on Aspergillus fumigatus chromosome 2 encodes a fatty acid desaturase with a cytochrome b5-like heme/steroid-binding domain and EC 1.14.19.18 activity, acting as an oxidoreductase on paired donors with molecular oxygen reduction. The gene is associated with unsaturated fatty acid metabolism, glucosylceramide anabolism, sphingolipid metabolism, fatty acid metabolism, lipid metabolism, and plasma membrane organization, and its product localizes to membranes. Related genes in other species, including Verticillium dahliae and Fusarium oxysporum strains, are linked to delta 8-(E)-sphingolipid desaturase activity, though this is not established for A. fumigatus.