HMG1 — Aspergillus fumigatus
Summary
AFU2G03700 (HMG1) in Aspergillus fumigatus encodes a hydroxymethylglutaryl-CoA reductase (NADPH) (EC 1.1.1.34). The gene is associated with isoprenoid anabolism, sterol anabolism, ergosterol anabolism, CoA metabolism, and N',N'',N'''-triacetylfusarinine C anabolism. HMG1 is also linked to biofilm formation, sporulation, phagocytosis, and cellular response to xenobiotic stimulus. The encoded protein localizes to the endoplasmic reticulum membrane, peroxisome membrane, and plasma membrane. Related genes in other species connect HMG1 homologs to reduced virulence.
Annotations
- Chromosome
- 2
- Related genes
- TLC1, HMG1, ASI3, CHO2, ASI1, DOA4, NSG1, RPL4B
- GO terms
- Phagocytosis, Biofilm Formation, ER membrane, plasmalemma, Sporulation, sterol anabolism, ergosterol anabolism, isoprenoid anabolism
- Publications
- 34849884, 22244335, 27216456, 22515269, 12181344, 27161319, 28180293, 22447934
- Traits
- RESISTANCE TO CHEMICALS: DECREASED, COMPETITIVE FITNESS: DECREASED, STRESS RESISTANCE: DECREASED, INVIABLE, RESISTANCE TO CHEMICALS: INCREASED, CELL CYCLE PROGRESSION: ABNORMAL, NUCLEAR POSITION: ABNORMAL, RESISTANCE TO CHEMICALS: NORMAL