fgaOx3 — Aspergillus fumigatus

Summary

AFU2G04060 (fgaOx3) on Aspergillus fumigatus chromosome 2 encodes an NADH:flavin oxidoreductase/NADH oxidase family protein with oxidoreductase activity acting on the CH-NH group of donors with NAD or NADP as acceptor, NADPH dehydrogenase activity, and FMN binding. The gene is associated with alkaloid anabolism, specifically ergot alkaloid and fumigaclavine C anabolism, as well as indole alkaloid anabolism and secondary metabolism. It has also been linked to apoptotic process and biofilm formation. Related genes in other species link the family to oxidoreductase activity (EC 1.3.1.100) and NADPH dehydrogenase activity (EC 1.6.99.1).