aox — Aspergillus fumigatus

Summary

AFU2G05060 (symbol aox) in Aspergillus fumigatus chromosome 2 encodes a protein with the AOX_sf domain family, alternative oxidase activity, and metal binding. This gene is associated with alternative respiration, cellular respiration, the electron transport chain, electron transfer, gluconeogenesis, oligosaccharide anabolism, heterotrophy, cellular response to oxidative stress, and detoxification. The product localises to the mitochondrial inner membrane, mitochondria, and respirasome. Studies of related genes in other species link the family to oxidative stress response, unaffected pathogenicity, and aspergillosis, though these associations are not established for this gene itself.