acuK — Aspergillus fumigatus

Summary

AFU2G05830 (symbol acuK) on Aspergillus fumigatus chromosome 2 encodes a Zn2Cys6 DNA-binding transcription factor that binds RNA polymerase II regulatory regions and zinc ions. The gene is associated with gluconeogenesis, the glyoxylate cycle, alternative respiration, siderophore anabolism, reductive iron assimilation, heterotrophy, and cellular response to starvation. It has also been connected to translation, detoxification, homeostasis, and positive regulation of metabolism. The encoded protein localises to the nucleus. Studies of related transcription activators of gluconeogenesis in other fungi link the family to these same metabolic processes, though this is not yet established for A. fumigatus.