pptA — Aspergillus fumigatus

Summary

AFU2G08590 (symbol pptA) on Aspergillus fumigatus chromosome 2 encodes a phosphopantetheinyltransferase with EC 2.7.8.7 activity, belonging to the 4'-phosphopantetheinyl transferase superfamily and containing an AASDHPPT_N domain. The enzyme has phosphopantetheinyltransferase activity and binds magnesium. This gene is associated with multiple biosynthetic pathways, including DHN-melanin biosynthesis, gliotoxin, fumagillin, fumigaclavine C, fumiquinazoline C, N',N'',N'''-triacetylfusarinine C, and lysine anabolism, as well as general secondary metabolism and pigmentation processes. The product localizes to the cytosol. Studies of related genes in other species link the family to loss of pathogenicity and pulmonary aspergillosis, with experimental models including Galleria mellonella and Mus musculus.