laeA — Aspergillus fumigatus

Summary

AFU2G11400 (laeA) in Aspergillus fumigatus chromosome 2 encodes a methyltransferase type 11 domain-containing protein with methyltransferase activity. This nuclear protein is associated with developmental growth, autolysis, tube formation, pigmentation, and angiogenesis. It is linked to sterigmatocystin metabolism, gliotoxin anabolism, fumagillin anabolism, fumigaclavine C anabolism, endocrocin anabolism, penicillin metabolism and its positive regulation, siderophore anabolism, methionine metabolism, the shikimate pathway, metabolic burst, and response to superoxide. Additionally, laeA is associated with germination rate, oxidative stress response, and positive regulation of ascospore formation. Related genes in other species link the family to similar roles in development.