OTA — Aspergillus fumigatus

Summary

AFU2G12470 (OTA) in Aspergillus fumigatus encodes a pyridoxal phosphate-dependent aminotransferase with L-ornithine transaminase and N2-acetylornithine 5-aminotransferase activities (EC 2.6.1.11). The gene is associated with ornithine metabolism, arginine anabolism, the urea cycle, L-proline biosynthesis, immune response, macrophage activation, and secretion. Its product localises to the mitochondrial lumen, cytoplasm, cytosol, and nucleus. The gene has been linked to protein content, and to numerous phenotypes including altered cell cycle progression, endocytosis, autophagy, biofilm formation, flocculation, nutrient uptake and utilization, osmotic stress resistance, ionic stress resistance, alkaline pH resistance, freeze-thaw resistance, killer toxin resistance, actin cytoskeleton morphology, bud morphology, colony appearance, and chromosome segregation. Studies of related genes in other species connect the family to filamentous growth, innate thermotolerance, and replicative lifespan.