BCS1 — Aspergillus fumigatus

Summary

AFU2G14760 (AfBCS1, BCS1) on chromosome 2 encodes a BCS1-like ATPase with ATP-dependent peptidase, metalloendopeptidase, and protein carrier activities, and binds ATP and zinc. It is associated with mitochondrial cytochrome bc(1) complex assembly, protein insertion into the mitochondrial inner membrane, mitochondrial protein quality control and processing, proteasomal protein catabolism, sporulation, and homeostasis. The gene is linked to the M-AAA complex, proteasome regulatory particle, mitochondrial inner membrane, nuclear periphery, and chromatin. Phenotypic associations include absent respiratory metabolism and spore germination, decreased mitochondrial transport and cell cycle progression in S phase, increased petite frequency and pseudohyphal growth, and altered vegetative growth and carbon source utilization. Related genes in other species are linked to acid sensitivity and oxidative stress response.