arp2 — Aspergillus fumigatus

Summary

AFU2G17560 (symbol arp2) in Aspergillus fumigatus chromosome 2 encodes a short-chain dehydrogenase/reductase (SDR) family protein with tetrahydroxynaphthalene reductase activity and broader oxidoreductase activity acting on CH-OH group donors. The gene is associated with DHN-melanin biosynthesis, pigmentation, melanin anabolism, and L-phenylalanine breakdown, as well as phagocytosis. Its product localises to the endosome. Related genes in other species link the family to melanin pigment production.