fgaPT1 — Aspergillus fumigatus

Summary

AFU2G17990 (fgaPT1) on chromosome 2 of Aspergillus fumigatus encodes a dimethylallyltransferase (EC 2.5.1.100) belonging to the DMATS-type aromatic prenyltransferase family, with additional aminopeptidase activity (EC 3.4.11.17). The gene product is associated with prenylation and proteolysis, and is linked to the biosynthesis of alkaloids, specifically ergot alkaloids and fumigaclavine C. It also has connections to protein homodimerization activity. Studies of related genes in other species link this family to prenyltransferase activity (EC 2.5.1.34) and have been investigated in contexts including murine models and invasive pulmonary aspergillosis, though these associations are not established for fgaPT1 itself.