PMB — Aspergillus fumigatus

Summary

AFU3G01560 (PMB, AfPMB) encodes a putative amino acid permease of the APC family, with basic amino acid permease activity and L-arginine, L-lysine, and L-histidine transmembrane transporter activity. The gene is associated with the plasma membrane, eisosome, Golgi membrane, and cell tip. It is associated with biological processes including basic amino acid transport, regulation of nitrogen utilization, innate immunity, phagocytosis, immune evasion, biofilm formation, secretion, meiotic cell cycle, ergosterol anabolism, and protein breakdown. Phenotypic associations include abnormal nitrogen utilization, increased polyploidy and aneuploidy, decreased cell death and apoptosis, increased pseudohyphal growth, altered cell cycle progression, decreased cold sensitivity, and abnormal plasma membrane morphology. Studies of related genes in other species link the family to reduced virulence and altered biofilm formation.