mirB — Aspergillus fumigatus

Summary

AFU3G03640 (mirB) on chromosome 3 of Aspergillus fumigatus encodes a major facilitator superfamily (MFS) transporter with iron-siderophore transporter activity. The gene is associated with siderophore metabolism, specifically ferric triacetylfusarinine C import into the cell and siderophore-iron import, as well as cellular response to iron ion starvation, iron transport, membrane transport, and homeostasis. The encoded protein localizes to the cytoplasmic vesicle membrane, cell tip, plasmalemma, and membrane. mirB has been linked to invasive pulmonary aspergillosis in a Mus musculus model.