sC — Aspergillus fumigatus

Summary

AFU3G06530 (sC) on Aspergillus fumigatus chromosome 3 encodes a protein with ATP:sulfate adenylyltransferase and adenylylsulfate kinase activities, and is annotated to sulfate assimilation, hydrogen sulfide anabolism, and cysteine anabolism. Its product localises to the cytoplasm. The gene is associated with increased vegetative growth, pseudohyphal growth, and survival in stationary phase, as well as altered autophagy, pexophagy, and prion inheritance. It is also associated with decreased cold sensitivity, increased hyperosmotic stress resistance, and changes in respiratory and fermentative metabolism. Related genes in other species, such as yeast MET3, connect the family to sulfate assimilation, and sequence similarity links to fungal pathogens including Verticillium dahliae and Fusarium oxysporum suggest possible connections to virulence.