ega3 — Aspergillus fumigatus

Summary

AFU3G07890 (ega3) on Aspergillus fumigatus chromosome 3 encodes a protein with melibiase activity (EC 3.2.1.22) and belongs to the glycoside hydrolase family, containing GH114_TIM-barrel and aldolase_TIM domains. The gene is associated with cell wall polysaccharide anabolism, glycan biosynthesis, and nucleotide-sugar metabolism, as well as with biofilm formation, secretion, and homeostasis. Studies of related genes in other species link the family to cytoplasmic effector functions, though this has not been established in A. fumigatus. The gene is also related to EGA3, described as alpha-1.