MSH2 — Aspergillus fumigatus

Summary

AFU3G09850, designated AfMSH2, encodes a protein with domains characteristic of the DNA mismatch repair MutS family, including Msh2_ATP-bd, DNA_mismatch_repair_Msh2, and MutS domains. It has ATP hydrolase activity and binds mispaired bases, G/T mismatches, heteroduplex DNA loops, Holliday junctions, and Y-form DNA. The gene is associated with multiple DNA repair and recombination processes, including mismatch repair, removal of nonhomologous ends, maintenance of DNA repeat elements, meiotic mismatch repair and gene conversion, replication fork arrest, interstrand crosslink repair, and mitotic recombination. It is also linked to silencing at the mating-type locus and DNA replication. The protein localizes to the nucleus, nuclear chromosome, and cytosol. Phenotypic associations include absent X-ray and UV resistance, increased transposable element transposition, absent mitotic recombination, altered cell cycle progression, abnormal chronological lifespan, decreased lifespan, delayed sporulation, and abnormal telomere length.