pacC — Aspergillus fumigatus

Summary

AFU3G11970, designated pacC and also known as RIM101 or AfRIM101, encodes a C2H2 zinc-finger transcription factor of the pacC/RIM101 family on chromosome 3 of Aspergillus fumigatus. The product binds sequence-specific DNA and zinc ions. This gene is associated with cellular responses to basic pH, zinc import, nuclear import, calcium signaling, signal transduction, positive regulation of transcription by RNA polymerase II, DNA-dependent transcription, and homeostasis. It is associated with hyphal growth, host invasion, and immune response. The protein localises to both the cytoplasm and nucleus. Clinically, pacC is linked to pulmonary aspergillosis, and studies in Mus musculus have explored its role. Related genes in other species are linked to pH response and sugar content.