BCS1 — Aspergillus fumigatus

Summary

AFU3G13000 (AfBCS1, BCS1) on chromosome 3 of Aspergillus fumigatus encodes a putative mitochondrial chaperone BCS1, a member of the AAA+ ATPase family with ATP hydrolase, metalloendopeptidase, and protein carrier/transporter activities. The gene is associated with mitochondrial cytochrome bc1 complex assembly, protein insertion into the mitochondrial membrane from the inner side, mitochondrial protein quality control and processing, protein unfolding, and peroxisome matrix protein import. It is linked to the M-AAA complex, ATPase complex, and mitochondrial membranes. Phenotypic associations include absent respiratory metabolism and spore germination, decreased mitochondrial transport, cell cycle progression in S phase, and chitin deposition, as well as increased pseudohyphal growth and survival rate in stationary phase. Related genes in other species are associated with oxidative stress response and acid sensitivity.