AUS1 — Aspergillus fumigatus

Summary

AFU4G01050 (symbol AUS1, also known as abcG) encodes an ABCG-type pleiotropic drug resistance (PDR) transporter with ATP-coupled transmembrane transporter activity, ATP hydrolase activity and ATP binding. In Aspergillus fumigatus, this gene is associated with steroidogenesis and ergosterol anabolism, xenobiotic detoxification via export across the plasma membrane, response to antibiotics, mating, carbohydrate metabolism, cell growth, and hypersensitivity. The product localises to the plasma membrane. Phenotypic associations include abnormal small molecule transport, increased sporulation rate, decreased cell death rate, delayed mitophagy, altered replicative and chronological lifespan, abnormal pseudohyphal growth, and altered nutrient uptake. Related genes in other species link the family to multidrug resistance and sterol transport, while distant sequence similarity connects the family to plant traits such as leaf number, plant height, root length, drought tolerance, and phosphate content.