AIM2 — Aspergillus fumigatus

Summary

AFU4G01130 (AfAIM2, AIM2) on chromosome 4 of Aspergillus fumigatus encodes a protein containing a dienelactone hydrolase domain and an alpha/beta hydrolase fold, with predicted hydrolase activity (EC 3.1.1.-). The gene is annotated to membrane biogenesis. Phenotypic associations link AfAIM2 to altered carbon source utilization, decreased heat sensitivity, decreased stress resistance, and both increased and decreased oxidative stress resistance. It is also associated with abnormal vacuolar morphology, decreased vegetative growth rate, altered competitive fitness (both increased and decreased), and variable chemical resistance. Studies of related genes in other species connect the family to abnormal mitochondrial genome maintenance, decreased filamentous growth, absent invasive growth, and increased metal resistance.