icsA — Aspergillus fumigatus

Summary

AFU4G01370 (symbol icsA) on Aspergillus fumigatus chromosome 4 encodes a protein containing an isocyanide synthase DIT1 domain and a TauD/TfdA-like domain, and is annotated with ligase, isomerase and redox activities. This gene is associated with tryptophan breakdown and secondary metabolism, as well as with the oxidative stress response. Studies of related genes in other species link the family to pyoverdine/dityrosine biosynthesis and to a ligase activity (EC 6.3.2.-).