fluG — Aspergillus fumigatus

Summary

AFU4G03710 (fluG) on chromosome 4 of Aspergillus fumigatus encodes a protein with glutamine synthetase and hydrolase activities, ATP binding, and a glutamine synthetase catalytic domain. The gene is associated with amine metabolism, autolysis, hyphal growth, and asexual reproduction, including positive regulation of conidium formation and sporocarp development. It is linked to the regulation of sterigmatocystin and aflatoxin biosynthetic processes, as well as broader secondary metabolism and sterol metabolism. The encoded product localizes to the cytoplasm. Studies of related genes in other species connect the family to oxidative stress response, though this has not been established in A. fumigatus.