RHD — Aspergillus fumigatus

Summary

AFU4G08580, symbol RHD and also known as prx1, encodes a mitochondrial peroxiredoxin Prx1, putative, in Aspergillus fumigatus. The product belongs to the peroxiredoxin family, specifically the 1-Cys peroxiredoxin and AhpC/TSA subfamilies, and possesses thioredoxin-dependent peroxiredoxin activity, peroxidase activity, and protein-disulfide reductase activity (EC 1.11.1.7). This gene is associated with cellular responses to oxidative stress, including response to hydrogen peroxide, cellular detoxification of hydrogen peroxide, and cell redox homeostasis. It has also been linked to filamentous growth in response to chemical stimulus and starvation, fungal-type cell wall organization, actin cytoskeleton organization, and interaction with host. The protein localizes to the cytoplasm, nucleus, and hyphal cell wall. Studies of related genes in other species link the family to thioredoxin peroxidase activity.