OTA — Aspergillus fumigatus

Summary

AFU4G09140 (OTA, also known as car2) encodes a class-III pyridoxal-phosphate-dependent aminotransferase with L-ornithine transaminase and N2-acetylornithine 5-aminotransferase activity (EC 2.6.1.13). The gene is associated with ornithine metabolism, arginine anabolism, the urea cycle, L-proline biosynthesis, and macrophage activation. It is linked to immune response, secretion, and protein content. The product localises to the mitochondrial lumen, cytoplasm, cytosol, and nucleus. Phenotypic associations include altered endocytosis, cell cycle progression, autophagy, biofilm formation, flocculation, nutrient uptake and utilization, osmotic stress resistance, and abnormal actin cytoskeleton morphology. Related genes in other species link the family to filamentous growth, innate thermotolerance, and replicative lifespan.