DAP2 — Aspergillus fumigatus

Summary

AFU4G09320 (DAP2) encodes a dipeptidyl-peptidase with serine-type peptidase activity, classified as EC 3.4.14.5, and contains peptidase S9 and alpha/beta hydrolase domains. In Aspergillus fumigatus, this gene is associated with proteolysis, protein maturation, secretion, and membrane transport, as well as with fumagillin and ergosterol biosynthesis, morphogenesis, and the inflammatory and immune responses. It localizes to the extracellular region and plasma membrane. The gene has been linked to abnormal cell cycle progression, including G2/M arrest and increased G1 duration, decreased cell size, abnormal budding and colony morphology, increased apoptosis, and reduced freeze-thaw and killer toxin resistance. Studies of related genes in other species connect the family to sterility and decreased autophagy.