ABC2 — Aspergillus fumigatus

Summary

AFU4G10000 (ABC2, also known as mdr2) on Aspergillus fumigatus chromosome 4 encodes an ABC-type oligopeptide transporter with ATP-coupled transmembrane transporter activity and ATP hydrolase activity. The protein localises to the mitochondrial inner membrane, mitochondria, and plasmalemma. It is associated with D-amino acid metabolism, oligopeptide export from mitochondria, glutathione metabolism, response to toxic substances, autophagy, cell growth, cell cycle, and membrane transport. Phenotypic associations include altered oxidative and osmotic stress resistance, abnormal vacuolar morphology and distribution, increased pexophagy, decreased endocytosis, abnormal cell cycle progression, and changes in fermentative metabolism and entry into stationary phase. The gene is also linked to homologous recombination, MMR, and carbohydrate metabolism. Studies of related genes in other species connect the family to leaf width, leaf shape, salt tolerance, and oxidative stress response.