GCN5 — Aspergillus fumigatus

Summary

AFU4G12650 (GCN5, gcnE) in Aspergillus fumigatus encodes a histone acetyltransferase with GNAT and bromodomain motifs, classified as EC 2.3.1.48. The product exhibits histone H3K9, H3K14, H3K18, and H4K16 acetyltransferase activities, along with histone crotonyltransferase and reader activities for H3K56ac, H4K12ac, and H4K16ac. It localizes to chromatin, the nucleus, and complexes including ADA, SALSA, and SWR-C. The gene is associated with siderophore biosynthesis, heterochromatin boundary formation, DNA repair-dependent chromatin remodeling, biofilm formation, secondary metabolism, and positive regulation of RNA polymerase II transcription. Phenotypic associations include increased sporulation rate, altered cell cycle progression, increased carbon source utilization, and abnormal mitophagy. Related genes in other species are linked to oxidative stress response, acid sensitivity, and increased virulence.