SNX4 — Aspergillus fumigatus

Summary

AFU4G12950 (SNX4, also known as ATG24) in Aspergillus fumigatus encodes a protein containing Vps5_C, PX, and BAR-like domains, and is annotated to bind phosphatidylinositol-3-phosphate and phosphoinositides. The gene is associated with protein localization to the endosome, PGE to Golgi transport, the cytoplasm-to-vacuole targeting pathway, endocytic recycling, autophagy of mitochondrion, ER-phagy, PMN, mitophagy, hyphal growth, protein transport, and autophagy. It localizes to the external side of the endosome membrane, early endosome, perinuclear region of cytoplasm, PAS, PAS membrane, adiposome, endosome membrane, mitochondrial membrane, mitochondria, and cytosol. Phenotypic associations link SNX4 to decreased rates of autophagy and pexophagy, abnormal sporulation, delayed vacuolar transport, and altered adhesion and cell death. Studies of related genes in other species connect the family to virulence and stress responses, though these are not established for A. fumigatus.