atrA — Aspergillus fumigatus

Summary

AFU5G00150 (atrA) on chromosome 5 of Aspergillus fumigatus encodes a thioesterase domain protein with acid-thiol ligase activity, very long-chain fatty acid-CoA ligase activity, phosphopantetheine binding, and transferase activity. The gene is associated with calcium signaling, fatty acid anabolism, hyphal growth, spore formation, and DNA repair, and its product localizes to the cytoplasm. Studies of related genes in other species link the family to polyketide synthase thioesterase and AMP-binding domains, as well as EC numbers 6.4.1.10 and 2.3.1.-, though these functions are not established for atrA itself. The gene is also related to tdiA.