nscR — Aspergillus fumigatus

Summary

AFU5G01065, symbol nscR, on Aspergillus fumigatus chromosome 5, encodes a C6 transcription factor with a Zn2Cys6 DNA-binding domain. The product has DNA-binding transcription factor activity, RNA polymerase II-specific, and localises to the nucleus. This gene is associated with activation of secondary metabolite biosynthesis, positive regulation of metabolism, secondary metabolism, and response to FK506. Studies of related genes in other species connect the family to the regulation of secondary metabolite gene clusters, though this is not established for nscR itself.