PAR1 — Aspergillus fumigatus

Summary

AFU5G02560 (PAR1, AfPAR1) encodes a serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit, a member of the PP2A_B56 family with ARM-type fold domains. The gene product is associated with protein phosphatase activator activity, protein binding and bridging, and DNA binding. It localizes to the PP2A complex, kinetochore, meiotic spindle, centromere complex, spindle pole body, and cellular bud neck. PAR1 is associated with numerous cell cycle processes including chromosome biorientation, meiotic sister chromatid cohesion, septin ring disassembly, anaphase cohesion protection, and traversing the start control point of the mitotic cell cycle. It is also linked to hyphal growth, signal transduction, DNA repair, and dephosphorylation. Phenotypic associations include decreased cell cycle progression rate, decreased autophagy, abnormal sporulation efficiency, and altered mating type switching. The gene has been linked to pulmonary aspergillosis in mouse models.