BD — Aspergillus fumigatus

Summary

AFU5G05480 (symbol BD, preferred name AfBD) encodes a small Ras-type GTPase with GDP and GTP binding, GTPase activity, and protein serine/threonine kinase activator activity. The gene is associated with Ras protein signal transduction, small GTPase-mediated signal transduction, negative regulation of asexual sporulation, activation of L-arginine uptake, upregulation of TORC1 signaling, protein farnesylation, cell polarization, invasive growth, glucan and lysine anabolism, and responses to nitrogen starvation. It is linked to inflammatory and immune responses, and localises to the plasma membrane, cytosol and nucleus. Phenotypic associations include decreased vacuolar transport, absent bipolar budding, decreased redox state, increased mating-type switching, decreased rate of entry into G0, and absent osmotic and oxidative stress resistance. Studies of related genes in other species link the family to protein content and oxidative stress response.