ABC2 — Aspergillus fumigatus

Summary

AFU5G06070 (ABC2, also known as mdr1) in Aspergillus fumigatus encodes an ABC-type oligopeptide transporter with ATP hydrolase activity, belonging to the type 1 exporter family and containing AAA+ ATPase domains. The gene is associated with xenobiotic detoxification via transmembrane export across the plasma membrane, oligopeptide export from the mitochondrion, and response to antibiotics. It is linked to biofilm formation, hyphal growth, spore formation, calcium signaling, ergosterol and sterol anabolism, homologous recombination, cell cycle progression, and cell growth. Localization evidence connects the product to the fungal vacuole, mitochondrial inner membrane, and plasma membrane. Associations with traits include oxidative stress response, while phenotypes linked to the gene include altered vacuolar morphology, decreased endocytosis, abnormal cell cycle progression, and increased entry into G0 stationary phase.