NHX1 — Aspergillus fumigatus

Summary

AFU5G06220 (AfNHX1, NHX1) on Aspergillus fumigatus chromosome 5 encodes a sodium/hydrogen exchanger with potassium:proton antiporter activity, belonging to the NaH_exchanger and cation/H_exchanger CPA1 families. The gene is associated with sodium and potassium ion membrane transport, proton transmembrane transport, and vacuolar acidification. Its product localizes to the fungal-type vacuole membrane, Golgi membrane, early and late endosomes, and the trans-Golgi network. AfNHX1 is associated with absent biofilm formation, decreased spore germination rate, increased ionic stress resistance, increased X-ray resistance, abnormal autophagy and endocytosis, delayed protein transport, and altered cell cycle progression through G1/S and G2/M transitions. It is also associated with root length. Related genes in other species are linked to potassium concentration and acid sensitivity.