HOC1 — Aspergillus fumigatus

Summary

AFU5G08580 (HOC1, also known as och1) in Aspergillus fumigatus encodes a putative alpha-1,6-mannosyltransferase subunit belonging to the Och1-like family, with glycolipid 6-alpha-mannosyltransferase and 1,6-alpha-mannosyltransferase activities (EC 2.4.1.-). The gene is associated with N-glycan processing, glycoprotein and cell wall mannoprotein anabolism, and protein N-linked glycosylation. It is linked to the Golgi complex, ER membrane, and mannan polymerase complexes. HOC1 is associated with filamentous growth, sporulation, responses to heat and starvation, cell cycle progression, budding patterns, mating efficiency, pheromone sensitivity, shmoo formation, septum formation, protein secretion, and spore germination. Associations also include abnormal Golgi morphology, increased polyploidy, and sterile phenotypes. Studies of related genes in other species link the family to reduced virulence and oxidative stress response.