ISP6 — Aspergillus fumigatus

Summary

AFU5G09210 (ISP6, also known as alp2, AfPSP3, AfSPM1, or AfISP6) on chromosome 5 of Aspergillus fumigatus encodes a subtilisin-like serine endopeptidase (EC 3.4.21.63) belonging to the peptidase S8 family. The gene is associated with IgE binding, serine-type endopeptidase activity, and protein catabolic processes in the vacuole. It is linked to asexual sporulation, spore formation, morphogenesis, pexophagy, proteolysis, amino acid anabolism, inflammatory response, and immune response. The product localizes to the vacuole and extracellular space. Related genes in other species, such as vacuolar serine proteases, cerevisin, and the allergen Pen n 18, are linked by sequence similarity.