SDH2 — Aspergillus fumigatus

Summary

AFU5G10370 (SDH2, sdh2) on chromosome 5 of Aspergillus fumigatus encodes a protein with succinate dehydrogenase (quinone) and electron transfer activities, and contains domains including Succ_DH/fum_Rdtase_Fe-S, SDH/FRD_Iron-Sulfur, and 2Fe-2S_ferredoxin-type. The gene is associated with aerobic respiration, the TCA cycle, and oxidative phosphorylation from succinate to ubiquinone, and localises to the mitochondrial inner membrane as part of respiratory chain complex II. SDH2 is also associated with biofilm formation. Phenotypes annotated on this gene link it to increased alkaline and acid pH resistance, increased flocculation and sporulation efficiency, altered vegetative growth rates, increased apoptosis, decreased gamma-ray and freeze-thaw resistance, and abnormal cell cycle progression in G1 phase. Related genes in other species link SDH2 homologues to chemical resistance.