ATRR — Aspergillus fumigatus

Summary

AFU5G11240 (ATRR) on chromosome 5 of Aspergillus fumigatus encodes a member of the short-chain dehydrogenase/reductase (SDR) family with acylglycerone-phosphate reductase (NADP+) activity, oxidoreductase activity acting on CH-OH donors, and phosphopantetheine binding. The gene is associated with siderophore anabolism, reductive iron assimilation, ergosterol and sterol anabolism, phosphatidic acid anabolism, biofilm formation, hyphal growth, and secondary metabolite biosynthesis. It is linked to membrane, cytoplasm, cytosol, and nucleus localisation. Phenotypic associations include decreased vegetative growth, competitive fitness, oxidative stress resistance, UV resistance, desiccation resistance, and acquired thermotolerance, as well as increased toxin resistance, telomere length changes, and abnormal cell cycle progression through G2/M. Studies of related SDR family members in other species link the family to vegetative growth and competitive fitness.