SRE — Aspergillus fumigatus

Summary

AFU5G11260 (SRE, sreA) on Aspergillus fumigatus chromosome 5 encodes a GATA-family transcription factor with iron sensor activity, 2Fe-2S cluster binding, and DNA-binding transcription repressor activity specific to RNA polymerase II. The gene is associated with cellular iron ion homeostasis, response to iron and iron starvation, downregulation of ferrichrome anabolism and iron ion transport, siderophore metabolism and anabolism, reductive iron assimilation, heme anabolism, lysine anabolism, gluconeogenesis, gliotoxin anabolism, response to hypoxia, cellular response to copper, nitric oxide storage, cell killing, and oxidative stress response. The product localises to chromatin, cytoplasm, and nucleus. Studies of related genes in other species link the family to reduced virulence and polysaccharide content.