alp1 — Aspergillus fumigatus

Summary

AFU5G11940 (alp1) in Aspergillus fumigatus chromosome 5 encodes a putative tubulin-specific chaperone D, a protein that binds beta-tubulin and exhibits GTPase-activating protein (GAP) activity, and is annotated as a protein folding chaperone. The gene is associated with the post-chaperonin tubulin folding pathway, cytoplasmic microtubule organization, tubulin assembly, and microtubule cytoskeleton organization. It is also linked to protein folding, protein breakdown, secretion, ergosterol anabolism, sensitization, innate immunity, immune evasion, and phagocytosis. The encoded product localizes to the microtubule cytoskeleton, microtubules, mitotic spindle, cell division site, cytosol, and nucleus. Related genes in other species link the family to small nuclear ribonucleoprotein U1a and additional tubulin-specific chaperone D orthologues.