pkcA — Aspergillus fumigatus

Summary

AFU5G11970 (pkcA) on Aspergillus fumigatus chromosome 5 encodes a protein kinase C (PKC) with novel PKC activity (EC 2.7.11.13), containing C2, HR1, C1-like, and protein kinase domains, and exhibiting serine/threonine kinase, ATP-binding, zinc-binding, and lipid-binding activities. The gene is associated with positive regulation of the cell integrity MAPK cascade, regulation of fungal-type cell wall organization and biogenesis, regulation of cell shape and actin cytoskeleton organization, positive regulation of mitotic cytokinesis site selection, and regulation of mRNA processing body assembly and poly(A) tail shortening. It localizes to the actomyosin contractile ring, division septum, cell tip, stress granule, and site of polarized growth. Related genes in other species have been linked to reduced virulence and lethal phenotypes, and to oxidative stress response and germination rate.