KTR5 — Aspergillus fumigatus

Summary

AFU5G12160 (KTR5, also known as AfKTR5, AfOMH4, AfKTR7, AfOMH5, KTR7, OMH5, OMH4) on chromosome 5 of Aspergillus fumigatus encodes a putative alpha-1,2-mannosyltransferase (Kre5 family) with GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase and mannosylphosphate transferase activities. The gene is associated with N- and O-linked protein glycosylation, mannan and cell wall mannoprotein anabolism, fungal-type cell wall organization, cell-matrix and cell-cell adhesion, biofilm formation, asexual sporulation, conidia formation, cell growth, and mitigation of host defenses. Its product localizes to the Golgi, ER, plasma membrane, cytosol, and nucleus. Phenotypic associations include abnormal cell cycle progression, budding, cell size and shape, increased filamentous growth, decreased viability, and altered protein transport and chitin deposition. Related genes in other species are linked to reduced virulence.