hscA — Aspergillus fumigatus

Summary

AFU6G01910 (symbol hscA) on chromosome 6 of Aspergillus fumigatus encodes a C2H2 zinc finger domain protein, a putative transcription factor with DNA-binding, transcription activator and repressor activities, and 14-3-3 protein binding. The gene is associated with regulation of gene expression and transcription by RNA polymerase II, as well as calcium signaling, calcineurin-mediated signaling, cellular calcium ion homeostasis, and cellular response to calcium ions and acidic pH. It is also linked to exocytosis and cellular response to metal. The encoded protein localises to the nucleus, nucleoplasm, cytoplasm and cytosol. Studies of related genes in other species link the family to transcriptional regulation, though these associations are not yet established for hscA itself.