AHP1 — Aspergillus fumigatus

Summary

AFU6G02280 (symbol AHP1, also known as aspf3) on chromosome 6 of Aspergillus fumigatus encodes a thioredoxin-domain protein of the PRX5-like family with thioredoxin peroxidase (TPx) activity (EC 1.11.1.24) and protein homodimerization activity. The gene is associated with cell redox homeostasis, hydrogen peroxide catabolism, cellular response to oxidative stress, immune response, methanol metabolism, siderophore anabolism, secretion, and cellular osmotic response. The product localizes to the cytoplasm, cytosol, nucleus, mitochondria, peroxisome and its membrane, and is also found extracellularly. Associations with IgE binding and metal binding have been noted. Phenotypic links include abnormal redox state, increased lifespan, altered cell cycle progression (S-phase decreased, G1 increased duration), increased vegetative growth, absent filamentous and pseudohyphal growth, altered stress resistances (increased acid pH resistance, decreased gamma ray resistance), and changes in nutrient utilization, small molecule transport, protein secretion, and mitochondrial genome maintenance. Related genes in other species link the family to oxidative stress response.