BIA — Aspergillus fumigatus

Summary

AFU6G03660 (symbol BIA, preferred name AfBIA) in Aspergillus fumigatus chromosome 6 encodes a protein with dethiobiotin synthase activity (EC 6.3.3.3) and adenosylmethionine-8-amino-7-oxononanoate transaminase activity (EC 2.6.1.62), and binds pyridoxal phosphate, ATP, and magnesium. The gene is associated with biotin anabolism and sensitization, and its product localises to the mitochondrial lumen and mitochondria. Studies of related genes in other species link the family to these same biosynthetic steps. The BIA gene is also connected to the term amino-7-oxononanoate.